Safety Evaluation of Topical Valproate Application

Safety Evaluation of Topical Valproate Application

The potential role of topical valproate (VPA) in hair regrowth has been recently suggested. However, safety reports of VPA as a topical formulation are lacking. Therefore, in the present study, we investigated whether VPA causes skin irritation in humans. We first performed a cell viability test and showed that VPA did not exhibit toxicity toward HaCaT keratinocytes, fibroblasts, and RBL-3H mas...

Evaluation of topical application of honey in prevention of post-operative peritoneal adhesion formation in dogs

The objective of this study was to determine the effectiveness of topical administration of honey in prevention of or reduction in post-surgical peritoneal adhesions in dog. The study was conducted on 18 adultfemale mixed-breed dogs with a mean ± SD weight of 20 ± 4.25 kg. A standardized surgical trauma (serosaltrauma model) was made in the dogs’ descending colon to induce adhesion formation. T...

Safety of rapid intravenous loading of valproate.

BACKGROUND The introduction of IV valproic acid (VPA) has facilitated its use in situations where oral administration is not feasible. The present study was designed to evaluate the safety of administration of undiluted VPA (20 or 30 mg/kg/min) administered intravenously at rates of 6 or 10 mg/kg/min. METHODS Forty patients received a VPA loading dose (20 or 30 mg/kg) at 6 or 10 mg/kg/min. He...

Formulation and evaluation of curcumin gel for topical application.

The aim of the present investigation was to develop and study topical gel delivery of curcumin for its anti-inflammatory effects. Carbopol 934P (CRB) and hydroxypropylcellulose (HPC) were used for the preparation of gels. The penetration enhancing effect of menthol (0-12.5% w/w) on the percutaneous flux of curcumin through the excised rat epidermis from 2% w/w CRB and HPC gel system was investi...

Topical Application of Sulphanilamides